Synthesis of New Phosphate Nanomaterials “Pyrophosphates of Cerium” Application in Biomedicine

EasyChair Preprint 7819

Abstract

The use of effective contrast agents in magnetic resonance imaging (MRI) has become an international research challenge. The aim is to improve the diagnosis of some pathologies. The preparation of contrast agent by the solid-state method using efficient nanomaterials has attracted considerable attention due to its potential to interact with the physical stimulus, the objective is for the signal collected to be as intense as possible. Methods: This article proposes a simple method to prepare a nanomaterials based on pyrophosphates and doped with Gadolinium and Cerium from solid-state reagents. Firstly, the two phosphate nanomaterials (Pyrophosphate SrMP₂O₇) based on Gadolinium and Cerium (SrMP₂O₇ with M=Gd and Ce) were prepared at 1,000°C to develop pure phases, capable of increasing the contrast of the signal observed by MRI. The characterization of these nanomaterials was mad by several techniques: X-ray diffraction (XRD) to determine the mesh parameters; UV-visible to interpret optical properties and electronic properties; Fourier transform infrared spectroscopy (FT-IR) to characterize the functional groups of SrGdP₂O₇ and SrCeP₂O₇ nanomaterials. Results: The Gap energies values of two nanomaterials showed that the SrCeP₂O₇ has a better magnetic speed 1/T1 in comparison with the SrGdP₂O₇. Morever in T1 encoding, if the T1 relaxation time is short, the image is much clearer. However, T2 encoding implies that if the T2 relaxation time is short, the image is darker. Conclusion: Our nanomaterial based on Cerium SrCeP₂O₇ have a better longitudinal relaxation. then it can be an excellent positive contrast agent.

Keyphrases: Gap energy, Nanomaterials, Positive contrast agent, Pyrophosphate, medicine

@booklet{EasyChair:7819,
  author    = {Mohamed Faoussi and Bouazza Tbib and Salim Bounou},
  title     = {Synthesis of New Phosphate Nanomaterials “Pyrophosphates of Cerium” Application in Biomedicine},
  howpublished = {EasyChair Preprint 7819},
  year      = {EasyChair, 2022}}