Download PDFOpen PDF in browserTargeting Cancer's Achilles Heel: Pharmacophore Insights into Hsp90 Alpha InhibitionEasyChair Preprint 116326 pages•Date: December 27, 2023AbstractCancer, a formidable adversary, demands innovative therapeutic strategies that target its vulnerabilities effectively. Among these, Heat Shock Protein 90 (Hsp90) Alpha emerges as a critical player, holding the key to cancer cell survival and proliferation. This study employs pharmacophore insights to illuminate the structural nuances of Hsp90 Alpha inhibition, aiming to target cancer's Achilles heel. Utilizing consensus pharmacophore modeling, we dissect the essential features crucial for effective Hsp90 Alpha inhibition. The investigation reveals intricate relationships between lipophilic and hydrogen-bonding domains within inhibitors, providing a detailed pharmacophoric blueprint. This blueprint, akin to targeting cancer's Achilles heel, offers a strategic approach for the development of anti-cancer therapeutics. Keyphrases: Hsp90, Pharmacophore, modeling
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