Download PDFOpen PDF in browserSynthesis, Characterization of New Formazan Derivatives and Study of Biological and Anticancer ActivityEasyChair Preprint 797610 pages•Date: May 21, 2022AbstractThe aim of the research is the synthesis of formazan derivatives and the study of its biological activity and anticancer (breast cancer).The first step: reaction of the amino derivative 4-Methoxy-2-nitroaniline with Chloroacetyl Chloride to prepare the derivative (1), the second step: reaction of the derivative (1) with Hydrazine hydrate to prepare the derivative (2),the third step: the reaction of the derivative (2) with the Vanillin to prepare the Schiff base derivative (3), and the last step: included the reaction of the following amines (2-Amino benzimidazole, 3-Bromoaniline, 1-Phenol-2,3-dimethyl-4-aminopyrazolon-(5), 2-Amino-6-methoxybwnzothiazole) with sodium nitrite and hydrochloric acid to form diazonium salt which is reacted with Schiff base derivative (3) to prepare formazan derivatives (4-7). All the prepared derivatives were studied spectroscopically by means of a spectrum (FT-IR,1H-NMR,13C-NMR). Keyphrases: Anticancer activity, Formazan Derivatives, MCF-7, biological activity, breast cancer
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