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Synthesis, Characterization of New Formazan Derivatives and Study of Biological and Anticancer Activity

EasyChair Preprint 7976

10 pagesDate: May 21, 2022

Abstract

The aim of the research is the synthesis of formazan derivatives and the study of its biological activity and anticancer (breast cancer).The first step: reaction of the amino derivative 4-Methoxy-2-nitroaniline with Chloroacetyl Chloride to prepare the derivative (1), the second step: reaction of the derivative (1) with Hydrazine hydrate to prepare the derivative (2),the third step: the reaction of the derivative (2) with the Vanillin to prepare the Schiff base derivative (3), and the last step: included the reaction of the following amines (2-Amino benzimidazole, 3-Bromoaniline, 1-Phenol-2,3-dimethyl-4-aminopyrazolon-(5), 2-Amino-6-methoxybwnzothiazole) with sodium nitrite and hydrochloric acid to form diazonium salt which is reacted with Schiff base derivative (3) to prepare formazan derivatives (4-7). All the prepared derivatives were studied spectroscopically by means of a spectrum (FT-IR,1H-NMR,13C-NMR).

Keyphrases: Anticancer activity, Formazan Derivatives, MCF-7, biological activity, breast cancer

BibTeX entry
BibTeX does not have the right entry for preprints. This is a hack for producing the correct reference:
@booklet{EasyChair:7976,
  author    = {Luay A. Khaleel and Shaimaa Adnan},
  title     = {Synthesis, Characterization of New Formazan Derivatives and Study of Biological and Anticancer Activity},
  howpublished = {EasyChair Preprint 7976},
  year      = {EasyChair, 2022}}
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