Download PDFOpen PDF in browserDesign and Characterization of an Innovative Rodent Model, Human Skin and Immune System Humanized, for Investigating Skin Pathogen InfectionsEasyChair Preprint 123023 pages•Date: February 27, 2024AbstractThe human skin, serving as the primary barrier against pathogen transmission, is a pivotal focal point in infectious disease research. While rodent models have proven valuable for studying human-specific skin pathogens, the successful co-engraftment of human skin, autologous lymphoid tissues, and immune cells poses a persistent challenge. This study introduces the development of a groundbreaking human Skin and Immune System (hSIS)-humanized NOD-scid IL2Rγnull (NSG) mouse and Sprague–Dawley-Rag2tm2hera Il2rγtm1hera (SRG) rat models, involving the concurrent engraftment of full-thickness human fetal skin, autologous fetal lymphoid tissues, and autologous fetal liver-derived hematopoietic stem cells. Keyphrases: Humanized rodent models, Immunodeficient mice, Skin infections
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