Revolutionizing Dermatological Research: Humanized Rodent Models and Cutting-Edge Strategies for Skin Disease Modeling

EasyChair Preprint 12459

Abstract

This research delves into the creation and characterization of humanized mouse and rat models, incorporating full-thickness human skin grafts with the goal of closely replicating human physiology for applications in dermatological research, drug development, and transplantation studies. The paper meticulously outlines the methodology employed for generating these models, evaluates their viability, and explores the potential implications for advancing our comprehension of skin biology and pathology. Emphasizing the successful integration of full-thickness human skin into rodent hosts, the study points toward promising avenues for translational research within the field of dermatology. The subsequent section of the paper conducts a comprehensive review of immune-competent human skin disease models, highlighting their pivotal role in drug discovery. This review addresses current model limitations, explores innovative in vitro alternatives, scrutinizes diseases such as fibrosis, autoimmune disorders, psoriasis, cancer, and contact allergy, and underscores the necessity for superior non-animal, human immune-competent, and scalable skin disease models equipped with comprehensive biomarkers. Throughout, the paper underscores the urgent need for accurate drug discovery methodologies in line with ethical guidelines, notably the principles of the 3Rs (reduction, refinement, and replacement of animals in experiments).

Keyphrases: Dermatological Research, Humanized rodent models, Skin Disease Modeling

@booklet{EasyChair:12459,
  author    = {Liis Tammik},
  title     = {Revolutionizing Dermatological Research: Humanized Rodent Models and Cutting-Edge Strategies for Skin Disease Modeling},
  howpublished = {EasyChair Preprint 12459},
  year      = {EasyChair, 2024}}