Download PDFOpen PDF in browserProgress in the Field of Regenerative Medicine: from Engineered Human Skin Models to Clinical ApplicationsEasyChair Preprint 123453 pages•Date: March 1, 2024AbstractContinual advancements in regenerative medicine, along with the emergence of tissue-engineered skin products, offer promising prospects for tackling diseases lacking permanent cures. Our research laboratory has successfully crafted fibrin-based human skin, showcasing its effectiveness in permanent regenerative therapies. By employing orthotopic grafting onto immunodeficient mice, we have established a distinctive skin-humanized mouse model, providing a platform for investigating various monogenic skin diseases. This model has proven invaluable for evaluating gene therapy interventions for cell correction, especially in the context of psoriasis, a persistent inflammatory condition. This breakthrough addresses the crucial need for dependable humanized animal models to comprehend disease pathogenesis and pioneer innovative therapeutic approaches. Keyphrases: Human Skin Models, clinical applications, regenerative medicine
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