Transforming Drug Discovery: Progress and Future Perspectives in Immune-Competent Human Skin Disease Models

EasyChair Preprint 12256

Abstract

Skin diseases, inherently characterized by a significant immune component, present a formidable hurdle in drug development due to disparities in animal and human immunology. This exhaustive review explores the realm of immune-competent human skin disease models, emphasizing their crucial role in advancing drug discovery. Addressing pivotal issues in current models, such as inadequate prediction of human immune responses, the review navigates innovative in vitro alternatives, with a focus on co-cultures and 3D organotypic systems. Diseases including fibrosis, autoimmune disorders, psoriasis, cancer, and contact allergy are scrutinized, offering a detailed analysis of pathology and available models. Recognizing the limitations of existing models underscores the need for superior non-animal, human immune-competent, and scalable skin disease models featuring comprehensive biomarkers. Additionally, the review directs attention to areas requiring future development, including the integration of diverse immune cells and scalability. The pressing demand for accurate drug discovery methodologies aligned with ethical guidelines, such as the 3Rs (reduction, refinement, and replacement of animals in experiments), is emphasized.

Keyphrases: Immune-Competent Models, Skin diseases, drug discovery

@booklet{EasyChair:12256,
  author    = {Isabella Rossi},
  title     = {Transforming Drug Discovery: Progress and Future Perspectives in Immune-Competent Human Skin Disease Models},
  howpublished = {EasyChair Preprint 12256},
  year      = {EasyChair, 2024}}