Synthesis and Characterization of Captopril Co-Crystals with Two Amino Acids

EasyChair Preprint 6321

Abstract

In pharmaceutical industry theirs more then 60-70% of active pharmaceutical ingredients (APIs) could not enter the ultimate market because of their pretty poor water solubility , The success of approaching high water solubility depends on physical and chemical nature of molecules being developed so, the co-crystallization of drug substances offers a great opportunity for the development of new drug products with superior physicochemical such as melting point, stability, solubility, dissolution, bioavailability, permeability The aim of present research work was to prepare co-crystals of captopril with two amino acid as co-formers l-proline and l-arginine. The preparation was with different ratios like 1:1, 1:2, 1:3 using “green process”, liquid assisted grinding and solvent evaporation method respectively to overcome low aqueous solubility, dissolution and stability problems associated with captopril to improve its effectiveness. Physical nature of captopril and prepares cocrystals were characterized by differential scanning calorimetry (DSC), the investigation was report for solid–liquid equilibria of binary mixtures, captopril with , l-arginine and l-proline, resulting in a temperature-composition phase diagrams with eutectic equilibrium. Eutectic mole fractions, temperatures, enthalpies and co-crystal formation

Keyphrases: DSC, amino acid, captopril, co-crystals and co-formers, phase diagrams

@booklet{EasyChair:6321,
  author    = {Houache Omar Elfarouk and Allal Farida and Dahmani Abdallah and Bouzida Abderrezak and Saidat Boubakeur},
  title     = {Synthesis and Characterization of Captopril Co-Crystals with Two Amino Acids},
  howpublished = {EasyChair Preprint 6321},
  year      = {EasyChair, 2021}}